Journal of General Physiology

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Journal of General Physiology The Journal of General Physiology publishes research in physiological problems at cellular and molecular level. Published by Rockefeller University Press.

The Journal of General Physiology publishes peer-reviewed research in biological, chemical, or physical mechanisms of broad physiological significance, with an emphasis on physiological problems at the cellular and molecular level. Areas include, but are not limited to:

- Membrane protein physiology
- Protein structure and dynamics
- Lipid and membrane biophysics
- Cell mechanics
- Intracellular and intercellular signaling

All editorial decisions are made by research-active scientists in conjunction with in-house scientific editors. JGP provides free online access to many article types from the date of publication and to all archival content. Established in 1918, JGP is published by The Rockefeller University Press. For more information, visit http://jgp.rupress.org. Follow us on Twitter: https://twitter.com/JGenPhysiol

Ashwini Hariharan, Thomas A. Longden et al. (University of Maryland) show that in a mouse model of disease, capillary ...
10/15/2026

Ashwini Hariharan, Thomas A. Longden et al. (University of Maryland) show that in a mouse model of disease, capillary blood flow control fails early: endothelial Kir2.1 currents decline at 2–4 mo, followed by pericyte KATP channel impairment by 6–8 mo. https://hubs.la/Q04BhpRy0

Jae Won Kwon, Sung Joon Kim, Young Keul Jeon et al. (Seoul National University) show that myofilament-associated nNOS pr...
10/05/2026

Jae Won Kwon, Sung Joon Kim, Young Keul Jeon et al. (Seoul National University) show that myofilament-associated nNOS preferentially restrains right ventricular contraction by regulating Ca²⁺-binding affinity through I phosphorylation. https://hubs.la/Q04z9r230

Toshiki Yamada, Erkan Karakas, and Jerod S. Denton (Vanderbilt University Medical Center) show that the prototypical LRR...
09/22/2026

Toshiki Yamada, Erkan Karakas, and Jerod S. Denton (Vanderbilt University Medical Center) show that the prototypical LRRC8/VRAC inhibitor DCPIB stabilizes an inactivated channel state through coordinated interactions spanning extracellular, transmembrane, & N-terminal channel domains https://hubs.la/Q04y2TDg0

KATP channels link a cell’s metabolic state to its electrical excitability through the binding of ADP/ATP to three class...
09/18/2026

KATP channels link a cell’s metabolic state to its electrical excitability through the binding of ADP/ATP to three classes of nucleotide-binding site. Priscilla Rubio, Michael C. Puljung et al. synthesize & characterize a fluorescent ATP derivative to probe the activity of these sites. https://hubs.la/Q04xSb7x0

Heart rate is controlled, in part, by the opening and closing of the ion channel HCN4. Lucas M. Blecker, John R. Banksto...
09/10/2026

Heart rate is controlled, in part, by the opening and closing of the ion channel HCN4. Lucas M. Blecker, John R. Bankston et al. (University of Colorado Anschutz) describe the functionally relevant domains of both the channel and its ER-resident potentiator, IRAG. https://hubs.la/Q04x8jvC0

“JGP is one of the increasingly rare journals where editorial decisions remain firmly centered on scientific merit. The ...
09/09/2026

“JGP is one of the increasingly rare journals where editorial decisions remain firmly centered on scientific merit. The review process is rigorous and fair, and the editors do not allow competitive pressures to override a balanced assessment of the science. Just as importantly, JGP continues to champion the work after publication, helping its significance reach the broader scientific community. Because the journal’s standards are trusted internationally, publication in JGP can lead to lasting visibility and recognition well beyond the immediate field. In our own experience, this increased visibility was followed by further international recognition, including scientific awards and a feature in Biomedical Picture of the Day (BPoD), supported by the University of Oxford.”— Chieko Koike, Ritsumeikan University

Learn more about JGP and publish in a journal that is trusted and read globally: https://hubs.la/Q04wXq7Y0

On our September cover (https://hubs.ly/Q04wKwHC0): Gaitán‑Peñas et al. (https://hubs.ly/Q04wKwyV0) show how the VRAC in...
09/07/2026

On our September cover (https://hubs.ly/Q04wKwHC0): Gaitán‑Peñas et al. (https://hubs.ly/Q04wKwyV0) show how the VRAC inhibitor DCPIB binds the extracellular selectivity filter through adaptable interactions, providing new insights into the molecular basis of channel inhibition.

New review: Magdalena Prantl, Lara Atzgerstorfer, Isabella Derler et al. (JKU - Johannes Kepler Universität Linz) catalo...
08/31/2026

New review: Magdalena Prantl, Lara Atzgerstorfer, Isabella Derler et al. (JKU - Johannes Kepler Universität Linz) catalog known disease-associated mutations, explain how they disrupt the activation sequence, and link them to their clinical impact. https://hubs.la/Q04vY4MX0

08/27/2026

Steffen S. Docken, Matthew J. Marquis, Kazuharu Furutani, Timothy J. Lewis, Jon T. Sack (UC Davis) and colleagues test the hypothesis that the antiarrhythmic drug nifekalant opens hERG gates while blocking, revealing a mechanism that may reduce risk. https://hubs.la/Q04vy_rs0

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